methionine-tRNA ligase, mitochondrial; methionyl-tRNA synthetase 2; mitochondrial methionyl-tRNA synthetase; MtMetRS (MARS2)

Function

-..........-

ATP + L-methionine + tRNA(Met)
       <-->
AMP + diphosphate + L-methionyl-tRNA(Met)

Kinetic parameters:

• KM=18 uM for Met, KM=85 uM for ATP, KM=2.1 uM for tRNA-Met
• Optimum pH is 7.8-8.2

Structure

• belongs to the class-I aminoacyl-tRNA synthetase family

Compartment

mitochondrial matrix

More general terms

• amino acyl tRNA synthetase-1
• mitochondrial protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96GW9.html