glutamate-tRNA ligase, mitochondrial; mitochondrial glutamyl-tRNA synthetase; GluRS (EARS2, KIAA1970)

Function

• catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP & then transferred to the acceptor end of tRNA(Glu)

ATP + L-glutamate + tRNA(Glu)
         <-->
AMP + diphosphate + L-glutamyl-tRNA(Glu)

Structure

• belongs to the class-I aminoacyl-tRNA synthetase family

Compartment

mitochondrial matrix

More general terms

• amino acyl tRNA synthetase-2
• mitochondrial protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=124454
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:124454
• OMIM: https://mirror.omim.org/entry/612799
• UniProt: http://www.uniprot.org/uniprot/Q5JPH6.html