phenylalanine-tRNA ligase, mitochondrial; mitochondrial phenylalanyl-tRNA synthetase; PheRS (FARS2, FARS1, HSPC320)

Function

• attachment of L-Phe to tRNA(Phe)
• may also catalyze attachment of p-Tyr (Tyr) & to a lesser extent m-Tyr to tRNA(Phe)

ATP + L-phenylalanine + tRNA(Phe)
           <-->
AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

Structure

• belongs to the class-II aminoacyl-tRNA synthetase family
• contains 1 FDX-ACB domain

Compartment

mitochondrial matrix

More general terms

• amino acyl tRNA synthetase-2
• mitochondrial protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10667
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10667
• OMIM: https://mirror.omim.org/entry/611592
• UniProt: http://www.uniprot.org/uniprot/O95363.html