sarcosine dehydrogenase, mitochondrial (SarDH, BPR-2)

Function

• choline metabolism

Sarcosine + acceptor + H2O
<-->
glycine + formaldehyde + reduced acceptor

Cofactor: FAD, covalently linked

Structure

belongs to the GcvT family

Compartment

mitochondrial matrix

Pathology

• defects in SARDH are a cause of sarcosinemia

More general terms

• dehydrogenase
• mitochondrial protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1757
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1757
• OMIM: https://mirror.omim.org/entry/268900
• OMIM: https://mirror.omim.org/entry/604455
• UniProt: http://www.uniprot.org/uniprot/Q9UL12.html