mitochondrial intermediate peptidase (MIP, MIPEP)

Function

• cleaves proteins, imported into the mitochondria, to their mature form
• release of an N-terminal octapeptide as 2nd stage of processing of some proteins imported into mitochondria
• activity is divalent cation-dependent; it is stimulated by Mn+2, Mg+2 or Ca+2 & reversibly inhibited by Zn+2, Co+2 & Fe+2/Fe+3

Cofactor:

• binds 1 Zn+2

Structure

monomer

Compartment

mitochondrial matrix

More general terms

• zinc metalloprotease
• mitochondrial protein

Database

• OMIM: https://mirror.omim.org/entry/602241
• UniProt: http://www.uniprot.org/uniprot/Q99797.html