nucleoside diphosphate kinase mitochondrial (NDP kinase mitochondrial, NDK, nm23-H4, NME4)

Function

• major role in the synthesis of nucleoside triphosphates other than ATP (putative)

ATP + nucleoside diphosphate <--> ADP + nucleoside triphosphate

Cofactor: Mg+2 (putative)

Structure

• homohexamer
• belongs to the NDK family

Compartment

mitochondria intermembrane space

Expression

• widely distributed
• found at very high levels in prostate, heart, liver, small intestine, & skeletal muscle tissues, & in low amounts in the brain & in blood leukocytes

More general terms

• nucleoside diphosphate kinase (NDK) or NDP kinase
• mitochondrial protein

Database

• OMIM: https://mirror.omim.org/entry/601818
• UniProt: http://www.uniprot.org/uniprot/O00746.html