3,2-trans enoyl CoA isomerase; dodecenoyl CoA delta-isomerase (DCI, ECI1)

Function

• converts cis or trans beta-gamma unsaturated fatty acyl CoA derivatives to trans alpha-beta unsaturated isomers
• able to isomerize both 3-cis & 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species
• fatty acid beta-oxidation cycle; auxiliary isomerization steps (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA

Structure

• homodimer (putative)
• belongs to the enoyl-CoA hydratase/isomerase family

Compartment

mitochondrial matrix

Alternative splicing

named isoforms=2

More general terms

• isomerase
• mitochondrial protein

More specific terms

• bifunctional peroxisomal enzyme [includes: enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; 3-hydroxyacyl-CoA dehydrogenase] (PBE, PBFE, EHHADH, ECHD)
• delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1)

Database

• UniProt: http://www.uniprot.org/uniprot/P42126.html