malic enzyme 3 (NADP-dependent malic enzyme mitochondrial, NADP-ME, ME3)

Function

• feeds into citric acid cycle
• malate from pyruvate

(S)-malate + NADP+ <--> pyruvate + CO2 + NADPH

Cofactor: divalent metal cations, prefers Mg+2 or Mn+2

Structure

belongs to the malic enzymes family

Compartment

mitochondrial matrix

Expression

• expressed predominantly in organs with a mitotic rate

More general terms

• malic enzyme, malate decarboxylase or malate oxidoreductase
• mitochondrial protein

Database

• OMIM: https://mirror.omim.org/entry/604626
• UniProt: http://www.uniprot.org/uniprot/Q16798.html