adenylate kinase-2 (AK2)

Function

• this small ubiquitous enzyme is essential for maintenance & cell growth

ATP + AMP <--> 2 ADP

Structure

• monomer (putative)
• belongs to the adenylate kinase family

Compartment

mitochondria intermembrane space

Alternative splicing

named isoforms=4

Expression

abundant in heart

Pathology

• deficiency of AK2 or AK3 results in decerebrate activity & death in infancy

More general terms

• adenylate kinase or adenyl kinase
• mitochondrial protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:204
• OMIM: https://mirror.omim.org/entry/103020
• UniProt: http://www.uniprot.org/uniprot/P54819.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=204