DNA polymerase gamma subunit 2, mitochondrial (mitochondrial DNA polymerase accessory subunit, PolG-beta, MtPolB, DNA polymerase gamma accessory 55 kDa subunit, POLG2, MTPOLB)

Function

• mitochondrial polymerase processivity subunit
• stimulates the polymerase & exonuclease activities, & increases the processivity of the enzyme
• binds to ss-DNA

Compartment

mitochondria

Pathology

• defects in POLG2 are the cause of autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 4

More general terms

• protein subunit
• mitochondrial protein

Component of

• DNA polymerase gamma

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1123
• OMIM: https://mirror.omim.org/entry/604983
• UniProt: http://www.uniprot.org/uniprot/Q9UHN1.html