deoxyribonuclease gamma (DNase gamma, deoxyribonuclease I-like 3, DNase I homolog protein DHP2, liver & spleen DNase, LS-DNase, LSD, DNASE1L3, DHP2, DNAS1L3)

Function

• has DNA hydrolytic activity
• does not bind to actin
• cleaves chromatin DNA to nucleosomal units

Cofactor: Ca+2, Mg+2

Inhibition:

• inhibited by Zn+2

Kinetic parameters: Optimum pH is about 7.2

Structure

• belongs to the DNase I family

Compartment

• nucleus
• may first pass through the ER membrane before import into the nucleus

Expression

expressed in liver & spleen

More general terms

• nuclear protein
• endodeoxyribonuclease

Database

• OMIM: https://mirror.omim.org/entry/602244
• UniProt: http://www.uniprot.org/uniprot/Q13609.html