protein ripply1 (RIPPLY1)

Function

• role in somitogenesis

essential for transcriptional repression of segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm

also required for the maintenance of rostrocaudal polarity insomites (putative)

Structure

• ripply homology domain is required for transcriptional repression (putative)
• WRPW motif is required for binding to TLE/GROUCHO proteins (putative)
• belongs to the ripply family

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

More general terms

• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q0D2K3.html