Pumilio domain-containing protein KIAA0020 (HBV X-transactivated gene 5 protein, minor histocompatibility antigen HA-8, HLA-HA8, KIAA0020, XTP5)

Structure

• contains 1 PUM-HD domain
• contains 6 pumilio repeats
• HA-8 region can be cleaved & exposed at cell surface where it plays a role as a minor histocompatibility HLA-A*0201- restricted antigen

Compartment

nucleus, nucleolus

Expression

widely expressed

Polymorphism

• alleles of HA-8: HA-8R, HA-8P, HA-8PL, of which only HA-8R leads to specific cytotoxic Tlymphocyte (CTL) recognition
• lack of CTL recognition of cells expressing HA-8P may be due to impaired transport associated with antigen processing

More general terms

• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q15397.html