repressor of RNA polymerase 3 transcription MAF1 homolog (MAF1)

Function

• element of the mTORC1 signaling pathway
• acts as a mediator of diverse signals
• inhibits RNA polymerase 3 transcription
• inhibits the de novo assembly of TFIIIB onto DNA
• phosphorylated at Ser-60, Ser-68 & Ser-75; the major sites of phosphorylation
• nuclear accumulation correlates with a concomitant dephosphorylation
• phosphorylation may attenuate its ability to inhibit RNA polymerase 3
• interacts with BRF2

Structure

belongs to the MAF1 family

Compartment

nucleus, cytoplasm

More general terms

• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84232
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84232
• OMIM: https://mirror.omim.org/entry/610210
• UniProt: http://www.uniprot.org/uniprot/Q9H063.html