major centromere autoantigen B; centromere protein B; CENP-B (CENPB)

Function

• interacts with centromeric heterochromatin in chromosomes
• binds to a specific subset of alphoid satellite DNA, called the CENP-B box
• may organize arrays of centromere satellite DNA into a higher order structure which then directs centromere formation & kinetochore assembly in mammalian chromosomes

Structure

• homodimer
• contains 1 HTH CENPB-type DNA-binding domain
• contains 1 HTH psq-type DNA-binding domain

Compartment

nucleus, centromere

Pathology

• autoantibody anti-centromere protein B antibody is seen in patients with cutaneous lupus erythematosus

Laboratory

• centromere protein B Ab in body fluid
  • centromere protein B Ab in CSF
  • centromere protein B Ab in serum
    • centromere protein B IgG in serum

More general terms

• nuclear protein
• phosphoprotein

Additional terms

• anti-centromere protein B antibody

Database

• UniProt: http://www.uniprot.org/uniprot/P07199.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1059
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1059
• OMIM: https://mirror.omim.org/entry/117140