epididymal sperm-binding protein 1 (epididymal secretory protein 12, hE12, ELSPBP1, E12)

Function

• binds to spermatozoa upon ejaculation & may play a role in sperm capacitation
• has phosphorylcholine-binding activity
• N-glycosylated

Structure

• belongs to the seminal plasma protein family
• contains 4 fibronectin type-2 domains

Compartment

secreted

Expression

• detected in cauda epididymidal fluid & on sperm membrane (at protein level)

More general terms

• secreted protein

Database

• OMIM: https://mirror.omim.org/entry/607443
• UniProt: http://www.uniprot.org/uniprot/Q96BH3.html