serine protease 33 (serine protease EOS, PRSS33)

Function

• serine protease that has amidolytic activity, cleaving its substrates before Arg residues

Kinetic parameters:

• KM=6.9 mM for H-DL-Val-Leu-Arg-pNA

Structure

• belongs to the peptidase S1 family
• contains 1 peptidase S1 domain

Compartment

secreted (putative)

Expression

• predominantly expressed in macrophages
• present in the spleen, small & large intestine, lung & brain (at protein level)
• highly expressed in peripheral leukocytes, ovary, retina, spleen & stomach
• moderately expressed in thymus, uterus & platelets, as well as some brain tissues, including thalamus & fetal brain
• up-regulated by phorbol ester PMA

More general terms

• secreted protein
• serine protease

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NF86.html