Sushi repeat-containing protein SRPX2 (SRPX2, SRPUL)

Function

• role in the perisylvian region, critical for language & cognitive development

Structure

• contains 1 HYR domain
• contains 3 Sushi (CCP/SCR) domains

Compartment

secreted

Pathology

• defects in SRPX2 are a cause of bilateral perisylvian polymicrogyria
• defects in SRPX2 are a cause of X-linked rolandic epilepsy with speech dyspraxia & mental retardation

More general terms

• secreted protein

Database

• OMIM: https://mirror.omim.org/entry/300388
• UniProt: http://www.uniprot.org/uniprot/O60687.html