guanylate cyclase activator 2B; contains: guanylate cyclase C-activating peptide 2; guanylate cyclase C-activating peptide II; GCAP-II; uroguanylin; UGN (GUCA2B)

Function

• endogenous activator of intestinal guanylate cyclase
• stimulates guanylate cyclase through the same receptor binding region as heat-stable enterotoxins
• physiological regulator of intestinal fluid & electrolyte transport
• autocrine/paracrine regulator of intestinal salt & water transport.

Compartment

secreted

Expression

stomach & intestine

More general terms

• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2981
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2981
• OMIM: https://mirror.omim.org/entry/601271
• UniProt: http://www.uniprot.org/uniprot/Q16661.html