lipocalin-1; Von Ebner gland protein; VEG protein; tear prealbumin; TP; tear lipocalin; Tlc (LCN1, VEGP)

Function

• could play a role in taste reception
• could be necessary for the concentration & delivery of sapid molecules in the gustatory system
• can bind various ligands, with chemical structures ranging from lipids & retinoids to the macrocyclic antibiotic rifampicin & even to microbial siderophores.
• exhibits an extremely wide ligand pocket
• binds to LMBR1L which may mediate its endocytosis

Structure

• homodimer (putative)
• belongs to the calycin superfamily, lipocalin family

Compartment

secreted

Expression

• mainly expressed in lacrimal & salivary glands.
• also expressed in the prostate

More general terms

• secreted protein
• lipocalin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3933
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3933
• OMIM: https://mirror.omim.org/entry/151675
• UniProt: http://www.uniprot.org/uniprot/P31025.html