phospholipase-A2 [PLA2] type 1 (pancreatic phospholipase-A2, snake venom phospholipase-A2, PLA2G1B)
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Function
- catalyzes the Ca+2-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides
phosphatidylcholine + H2O
<-->
1-acylglycerophosphocholine + a carboxylate
Cofactor: binds 1 Ca+2 per subunit (putative)
Structure
belongs to the phospholipase A2 family
Compartment
More general terms
References
- ↑ Mayer RJ, Marshall LA. New insights on mammalian phospholipase A2(s); comparison of arachidonoyl-selective and -nonselective enzymes. FASEB J. 1993 Feb 1;7(2):339-48. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8440410
- ↑ Glaser KB, Mobilio D, Chang JY, Senko N. Phospholipase A2 enzymes: regulation and inhibition. Trends Pharmacol Sci. 1993 Mar;14(3):92-8. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8488570