methylosome subunit pICln; Cl- conductance regulatory protein ICln, I[Cln]; Cl- channel, nucleotide sensitive 1A; Cl- current inducer protein; ClCI; reticulocyte pICln (CLNS1A, ICLN)

Function

• interaction with Sm proteins inhibits their assembly on U RNA
• interferes with snRNP biogenesis
• inhibits the binding of survival motor neuron protein (SMN) to Sm proteins
• may participate in cellular volume control by activation of a swelling-induced Cl- conductance pathway
• interacts with Sm proteins
• component of the methylosome

Structure

homooligomer

Compartment

cytoplasm, nucleus, cytoskeleton Small fraction is also associated with the cytoskeleton

More general terms

• protein subunit

Component of

• methylosome

Database

• OMIM: https://mirror.omim.org/entry/602158
• UniProt: http://www.uniprot.org/uniprot/P54105.html