CAAX farnesyltransferase alpha subunit (FNTA, RAS proteins prenyltransferase-alpha)

Function

• common farnesyl & geranylgeranyl transferase alpha-1 subunit
• catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a Cys at the fourth position from the C-terminus of several proteins having the C-terminal CaaX motif
• the alpha subunit is thought to participate in a stable complex with the substrate
• the beta subunit binds the peptide substrate
• heterodimer of an alpha & a beta subunit

farnesyl diphosphate + protein-Cys
              <-->
S-farnesyl protein + diphosphate

geranylgeranyl diphosphate + protein-Cys
                 <-->
S-geranylgeranyl-protein + diphosphate

Structure

• belongs to the protein prenyltransferase subunit alpha family
• contains 5 PFTA repeats

More general terms

• protein subunit

Component of

• prenyltransferase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2339
• OMIM: https://mirror.omim.org/entry/134635
• UniProt: http://www.uniprot.org/uniprot/P49354.html