non-gastric H+/K+ ATPase alpha subunit (K+ transporting ATPase alpha-like chain, ATP12A, ATP1AL1)

Function

• catalyzes hydrolysis of ATP coupled with exchange of H+ & K+ ions across the plasma membrane
• responsible for K+ absorption in various tissues
• composed of two subunits: alpha (catalytic) & beta

ATP + H2O + H+(in) + K+(out)
          <-->
ADP + phosphate + H+(out) + K+(in)

Structure

• belongs to the cation transport ATPase (P-type) family, type IIC subfamily

Compartment

membrane

Expression

found in skin & kidney

More general terms

• transmembrane 10 protein
• protein subunit

Database

• UniProt: http://www.uniprot.org/uniprot/P54707.html
• OMIM: https://mirror.omim.org/entry/182360
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=479