gastric H+/K+ ATPase alpha subunit (K+ transporting ATPase alpha chain 1, ATP4A)

Function

• catalyzes hydrolysis of ATP coupled with exchange of H+ & K+ ions across the plasma membrane
• responsible for acid production in the stomach

Structure

• belongs to the cation transport ATPase (P-type) family, type IIC subfamily

Compartment

membrane

Expression

found in gastric mucosa

More general terms

• transmembrane 10 protein
• protein subunit

Component of

• gastric H+/K+ ATPase (H+ transporting ATPase, K+ transporting ATPase, proton pump)

Database

• UniProt: http://www.uniprot.org/uniprot/P20648.html
• OMIM: https://mirror.omim.org/entry/137216
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=495