integrator complex subunit 6 (Int6, INTS6, protein deleted in cancer 1, protein DDX26, DBI-1, DBI1, DDX26, DDX26A)

Function

• component of the integrator complex
• role in tumor suppression (putative)
  • ectopic expression suppresses tumor cell growth

Structure

• contains 1 VWFA domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• widely expressed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas

Pathology

• frequently down-regulated in non small cell lung carcinomas & prostate cancers
• down-regulation in prostate cancer is due to CpG hypermethylation of its promoter

More general terms

• protein subunit

Component of

• integrator complex (multiprotein complex integrator)

Database

• OMIM: https://mirror.omim.org/entry/604331
• UniProt: http://www.uniprot.org/uniprot/Q9UL03.html