coiled-coil alpha-helical rod protein 1 (alpha helical coiled-coil rod protein, putative gene 8 protein, Pg8, CCHCR1, C6orf18, HCR)

Function

• regulates keratinocyte proliferation &/or differentiation (putative)

Compartment

• cytoplasm, nucleus

Expression

• expressed in all tissues
• expressed in heart, liver, skeletal muscle, kidney, pancreas > lung, placenta

Pathology

• overexpressed in keratinocytes of psoriatic lesions
• HCR is unlikely to be directly involved in psoriasis development

Polymorphism

• HCR*WWCC is associated with susceptibility to psoriasis
• association of HCR with psoriasis seem to be due to linkage disequilibrium with CW*0602

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/605310
• UniProt: http://www.uniprot.org/uniprot/Q8TD31.html