serologically defined colon cancer antigen 8; antigen NY-CO-8; centrosomal colon cancer autoantigen protein; hCCCAP (SDCCAG8, CCCAP, NPHP10, HSPC085)

Function

• role in the establishment of cell polarity & epithelial lumen formation (putative)
• may play a role in ciliogenesis
• interacts with OFD1

Structure

homodimer

Compartment

• cytoplasm, cytoskeleton, centrosome, centriole, cell junction
• located at the distal ends of both centrioles & colocalizes to centrosomes throughout the cell cycle
• isoform 2: cytoplasm

Alternative splicing

named isoforms=4

Expression

• expressed in thymus, prostate, testis, ovary, small intestine, colon, mucosa, colon

Pathology

• expressed in renal cancer
• defects in SDCCAG8 are the cause of Senior-Loken syndrome type 7

More general terms

• other protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10806
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10806
• OMIM: https://mirror.omim.org/entry/613524
• OMIM: https://mirror.omim.org/entry/613615
• UniProt: http://www.uniprot.org/uniprot/Q86SQ7.html