GTP cyclohydrolase 1 feedback regulatory protein; GFRP; GTP cyclohydrolase I feedback regulatory protein; p35 (GCHFR, GFRP)

Function

• mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I
• inhibition is reversed by L-phenylalanine
• forms a complex with GCH1 where a GCH1 homodecamer is sandwiched by two GFRP homopentamers
• interacts with GCH1

Structure

• homopentamer
• belongs to the GFRP family

Compartment

• nucleus, nuclear membrane, cytoplasm

Expression

• in epidermis, expressed predominantly in basal undifferentiated keratinocytes & in some but not all melanocytes (at protein level)

More general terms

• nuclear protein

Additional terms

• GTP cyclohydrolase (GTP cyclohydrolase 1, GTP dihydrolase, GTP ring-opening enzyme, GTP 8-formylhydrolase, GCH1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2644
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2644
• OMIM: https://mirror.omim.org/entry/602437
• UniProt: http://www.uniprot.org/uniprot/P30047.html