phosphoserine aminotransferase; phosphohydroxythreonine aminotransferase; PSAT (PSAT1, PSA)

Function

• amino-acid L-serine biosynthesis
  • step 2 in the synthesis of L-serine from 3-phospho-D-glycerate

O-phospho-L-serine + 2-oxoglutarate
           <-->
3-phosphonooxypyruvate + L-glutamate

Cofactor: pyridoxal phosphate

Structure

• homodimer
• belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family, SerC subfamily

Alternative splicing

named isoforms=2

Expression

• expressed in brain, liver, kidney, pancreas > thymus, prostate, testis, colon

Pathology

• defects in PSAT1 are the cause of phosphoserine aminotransferase deficiency

More general terms

• aminotransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29968
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:29968
• OMIM: https://mirror.omim.org/entry/610936
• OMIM: https://mirror.omim.org/entry/610992
• UniProt: http://www.uniprot.org/uniprot/Q9Y617.html