guanylyl cyclase-activating protein 1; GCAP 1; guanylate cyclase activator 1A (GUCA1A, GCAP, GCAP1, GUCA1)

Function

• stimulates guanylyl cyclase 1 (GC1) when free Ca+2 is low
• inhibits GC1 when free Ca+2 is elevated
• Ca+2-sensitive regulation of guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure
• binds three Ca+2

Structure

contains 4 EF-hand domains

Compartment

membrane; lipid-anchor

Expression

• retina cone outer & inner segments
• to a lesser extent rod inner & outer segments

Pathology

• defects in GUCA1A are the cause of cone dystrophy type 3

More general terms

• myristoylated protein
• Ca+2 binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/P43080.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2978
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2978
• OMIM: https://mirror.omim.org/entry/600364
• OMIM: https://mirror.omim.org/entry/602093