guanylin; guanylate cyclase activator 2A; guanylate cyclase-activating protein 1; gap-I; contains: HMW-guanylin; contains: guanylin (GUCA2A, GUCA2)

Function

• endogenous activator of intestinal guanylate cyclase
• stimulates intestinal guanylate cyclase through the same receptor binding region as the heat-stable enterotoxins

Structure

belongs to the guanylin family

Compartment

secreted

Expression

• highly expressed in ileum & colon
• found in plasma

More general terms

• secreted protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q02747.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2980
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2980
• OMIM: https://mirror.omim.org/entry/139392