striated muscle preferentially expressed protein kinase; aortic preferentially expressed protein 1; APEG-1 (SPEG, APEG1, KIAA1297)

Function

• serine/threonine kinase
• isoform 4 (non-kinase)
  • quickly down-regulated in response to vascular injury
  • may regulate growth & differentiation of arterial smooth muscle cells

Structure

• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family
• contains 2 fibronectin F3 modules
• contains 9 Ig-like (immunoglobulin-like) domains
• contains 2 protein kinase domains

Compartment

isoform 3: nucleus

Alternative splicing

• named isoforms=4;
• alternative promoter use

Expression

• isoform 1 is preferentially expressed in striated muscle
• isoform 4 (non-kinase) is predominantly espressed in the aorta
• expression regulated by locus control region

More general terms

• serine/threonine kinase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10290
• UniProt: http://www.uniprot.org/uniprot/Q15772.html