serine/threonine protein kinase Sgk2; serum/glucocorticoid-regulated kinase 2 (SGK2)

Function

• role in the activation of K+ channels
• two specific sites, one in the kinase domain (Thr-253) & the other in the C-terminal regulatory region (Ser-416), need to be phosphorylated for its full activation

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family
• contains 1 AGC-kinase C-terminal domain
• contains 1 protein kinase domain

Alternative splicing

named isoforms=3

Expression

• highly expressed in liver, kidney & pancreas, & at lower levels in brain

Notes

• not regulated by serum or glucocorticoids

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10110
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10110
• OMIM: https://mirror.omim.org/entry/607589
• UniProt: http://www.uniprot.org/uniprot/Q9HBY8.html