phosphoserine phosphatase; PSP; PSPase; L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase (PSPH)

Function

• catalyzes last step in the biosynthesis of serine from carbohydrates
• reaction proceeds via formation of phosphoryl-enzyme intermediates
• amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3

Cofactor: binds 1 Mg+2 per subunit

O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate

Inhibition: inhibited by Ca+2

Structure

• homodimer
• belongs to the serB family

Pathology

• defects in PSPH are the cause of phosphoserine phosphatase deficiency

More general terms

• serine/threonine phosphatase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5723
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5723
• OMIM: https://mirror.omim.org/entry/172480
• OMIM: https://mirror.omim.org/entry/614023
• UniProt: http://www.uniprot.org/uniprot/P78330.html