dipeptidyl aminopeptidase-like protein 6; dipeptidylpeptidase VI; dipeptidylpeptidase 6; dipeptidyl peptidase IV-like protein; dipeptidyl aminopeptidase-related protein; DPPX (DPP6)

Function

• may be involved in the physiological processes of brain function
• has no dipeptidyl aminopeptidase activity
• may modulate cell surface expression & the activity of K+ channel KCND2
• binds KCND2

Structure

• homodimer
• belongs to the peptidase S9B family

Compartment

membrane

Alternative splicing

named isoforms=2; DPPX-L, DPPX-S

Expression

expressed predominantly in brain

Pathology

• genetic variation in DPP6 may influence susceptibility to amyotrophic lateral sclerosis

Laboratory

• dipeptidyl aminopeptidase-like protein 6 IgG in CSF
• dipeptidyl aminopeptidase-like protein 6 IgG in serum/plasma

More general terms

• dipeptidase

Database

• UniProt: http://www.uniprot.org/uniprot/P42658.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1804
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1804
• OMIM: https://mirror.omim.org/entry/126141