peroxisomal leader peptide processing protease (trypsin domain-containing protein 1, [Contains: peroxisomal leader peptide processing protease, 10 kD form; peroxisomal leader peptide processing protease, 49 kD form], TYSND1)

Function

• peroxisomal protease
• mediates both removal of the leader peptide from proteins containing a PTS2 target sequence & specific processing of PTS1 proteins
• role in peroxisomal beta-oxidation of fatty acids (putative)
• processed into 49 kD & 10 kD forms upon import into peroxisomes
• 49 kD form probably corresponds to t mature enzyme
• 10 kD form may represent an inhibitory N-terminal fragment which prevents protease activity until it reaches peroxisomes

Structure

belongs to the peptidase S1B family

Compartment

peroxisome (putative)

Alternative splicing

named isoforms=2

More general terms

• protease; proteinase; endopeptidase

Database

• UniProt: http://www.uniprot.org/uniprot/Q2T9J0.html