beta-chimaerin (CHN2, rho GTPase-activating protein 3, rhoGAP3, arhGAP3, chimaerin-2)

Function

• GTPase-activating protein for p21rac

Structure

• contains 1 phorbol-ester/DAG-type Zn+2 finger
• contains 1 Rho-GAP domain
• contains 1 SH2 domain

Compartment

peripheral membrane

Alternative splicing

named isoforms=2

Expression

• expressed in brain & pancreas > heart, placenta > kidney & liver
• germ cell expression during acrosomal assembly in rat testes

Pathology

• expression is much reduced in the malignant gliomas, compared to normal brain or low-grade astrocytomas
• insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity & could therefore play a role in the progression from low-grade to high-grade tumors

More general terms

• rho GTPase-activating protein (rho-GAP)
• zinc finger protein

Database

• OMIM: https://mirror.omim.org/entry/602857
• UniProt: http://www.uniprot.org/uniprot/P52757.html