septin-10 (SEPT10)

Function

• filament-forming cytoskeletal GTPase.
• may play a role in cytokinesis
• septins polymerize into heterooligomeric protein complexes that form filaments, & can associate with cellular membranes, actin filaments & microtubules
• GTPase activity is required for filament formation (putative)

Structure

• belongs to the septin family

Compartment

• cytoplasm, cytoskeleton, nucleus

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• abundantly expressed in heart & kidney, placenta, skeletal muscles, liver & lung

Pathology

• expressed in various tumor cell lines

More general terms

• septin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=151011
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:151011
• OMIM: https://mirror.omim.org/entry/611737
• UniProt: http://www.uniprot.org/uniprot/Q9P0V9.html