neuronal-specific septin-3 (SEPT3, SEP3)

Function

• filament-forming cytoskeletal GTPase (putative)
• may play a role in cytokinesis (putative)
• phosphorylated by PKG on Ser-91 (putative)
• septins polymerize into heterooligomeric protein complexes that form filaments
• they associate with cellular membranes, actin filaments & microtubules
• GTPase activity is required for filament formation (putative)

Structure

belongs to the septin family

Compartment

• cytoplasm, cytoskeleton
• cell junction, synapse (putative)

Alternative splicing

named isoforms=3

Expression

• brain-specific expression
• up-regulated during neuronal differentiation

More general terms

• septin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55964
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55964
• OMIM: https://mirror.omim.org/entry/608314
• UniProt: http://www.uniprot.org/uniprot/Q9UH03.html