histone H2B type W-T (H2B histone family member W testis-specific, H2BFWT)

Function

• atypical histone H2B
• nucleosomes containing it are structurally & dynamically indistinguishable from those containing conventional H2B
• however, unlike conventional H2B, does not recruit chromosome condensation factors & does not participate in the assembly of mitotic chromosomes
• may be important for telomere function

Structure

• in contrast to other H2B histones, does not contain conserved residue in C-terminus that is target of monoubiquitination
• belongs to the histone H2B family

Compartment

nucleus membrane

Expression

• testis-specific
• present in sperm cells (at protein level)

Genetics

ortholog in primates, but not in rodents

More general terms

• histone-H2B
• testis-specific protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q7Z2G1.html