T-box transcription factor TBX6; T-box protein 6 (TBX6)

Function

• probable transcriptional regulator involved in developmental processes
• could be required for specification of paraxial mesoderm structures during gastrulation (putative)
• forms a dimeric complex with DNA (in vitro)

Structure

• contains 1 T-box DNA-binding domain

Compartment

nucleus (putative)

Expression

• expressed in fetal tail bud, posterior spinal tissue, intervertebral disk & testis
• also expressed in adult testis, kidney, lung, muscle & thymus
• expressed during gastrulation & during a second phase in some adult tissues

More general terms

• T-box (TBX) protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6911
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6911
• OMIM: https://mirror.omim.org/entry/602427
• UniProt: http://www.uniprot.org/uniprot/O95947.html