interferon regulatory factor 6 (IRF6)

Structure

• belongs to the IRF family
• contains 1 tryptophan pentad repeat DNA-binding domain

Compartment

nucleus (putative)

Pathology

• defects in IRF6 are a cause of:
  • van der Woude syndrome
  • popliteal pterygium syndrome
  • non-syndromic orofacial cleft type 6

More general terms

• interferon regulatory factor family

Database

• UniProt: http://www.uniprot.org/uniprot/O14896.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3664
• OMIM: https://mirror.omim.org/entry/119300
• OMIM: https://mirror.omim.org/entry/119500
• OMIM: https://mirror.omim.org/entry/607199
• OMIM: https://mirror.omim.org/entry/608864
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3664