class B basic helix-loop-helix protein 5; trinucleotide repeat-containing gene 20 protein (BHLHB5, BHLHE22,TNRC20)

Function

• inhibits DNA binding of TCF3/E47 homodimers & TCF3 (E47)/NEUROD1 heterodimers
• strong repressor of Neurod1 & Myod-responsive genes, probably by heterodimerization with class A basic helix-loop-helix factors
• despite presence of an intact basic domain, does not bind to DNA

Structure

contains 1 basic helix-loop-helix (bHLH) domain

Compartment

nucleus

Expression

brain-specific, highest expression in cerebellum

More general terms

• basic helix loop helix (bHLH) family transcription factor

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NFJ8.html