basic helix-loop-helix transcription factor scleraxis (SCXA, SCX, SCXB)

Function

• role in mesoderm formation
• later role in formation of somite-derived chondrogenic lineages
• efficient DNA binding requires dimerization with another bHLH protein
• dimerizes & binds the E-box consensus sequence with E12

Structure

contains 1 basic helix-loop-helix domain (bHLH)

Compartment

nucleus

More general terms

• basic helix loop helix (bHLH) family transcription factor

Database

• UniProt: http://www.uniprot.org/uniprot/Q7RTU7.html