transcription elongation factor A protein 3 (transcription elongation factor S-II protein 3, transcription elongation factor TFIIS.h, TCEA3 TFIISH)

Function

• facilitates RNA polymerase 2 transcription elongation past template-encoded arresting sites
• these arresting sites trap a some of the elongating RNA polymerase, resulting in block of transcription
• cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'terminus

More general terms

• transcription elongation factor
• DNA-binding protein
• zinc finger protein

Component of

• RNA polymerase-2

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6920
• OMIM: https://mirror.omim.org/entry/604128
• UniProt: http://www.uniprot.org/uniprot/O75764.html