brachyury protein; protein T (T)
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Function
- role in transcriptional regulation of genes required for mesoderm formation & differentiation
- binds to a palindromic site (called T site) & activates gene transcription when bound to such a site
- monomer (putative)
Structure
- contains 1 T-box DNA-binding domain
Compartment
Pathology
- genetic variations in protein T are associated with susceptibility to neural tube defects
- a protein T gene duplication is involved in susceptibility to the development of chordoma
More general terms
References
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6862
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6862
- OMIM: https://mirror.omim.org/entry/182940
- OMIM: https://mirror.omim.org/entry/215400
- OMIM: https://mirror.omim.org/entry/601397
- UniProt: http://www.uniprot.org/uniprot/O15178.html