protein phosphatase 2A regulatory subunit A beta (PP2A subunit A-PR65-beta isoform, PP2A subunit A-R1-beta isoform, PPP2R1B)

Function

• PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit & a variable regulatory B subunit
• interacts with IPO9

Structure

• each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop
• the repeat units may be arranged laterally to form a rod-like structure
• belongs to the phosphatase 2A regulatory subunit A family
• contains 15 HEAT repeats

Pathology

• defects in PPP2R1B might be a cause of some lung & colorectal cancers

More general terms

• phosphatase 2 regulatory subunit A

Additional terms

• phosphatase-2A (ceramide-activated protein phosphatase)

Database

• UniProt: http://www.uniprot.org/uniprot/P30154.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5519
• OMIM: https://mirror.omim.org/entry/603113
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5519