Zn+2 transporter 6 (ZnT-6, solute carrier family 30 member 6, SLC30A6, ZNT6)

Function

• Zn+2-efflux transporter which allocates the cytoplasmic Zn+2 to the trans-Golgi network (TGN) as well as the vesicular compartment (putative)
• hetero-oligomer
• interacts with ZNT5 (putative)
• appears to exert transport function by forming complexes with ZNT5

Structure

• belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily

Compartment

• trans-Golgi network
• found in vesicules

Alternative splicing

named isoforms=3

Expression

• expressed in brain, especially in cerebellum, hippocampus, parahippocampal gyrus, superior & middle temporal gyrus
• expressed in B cells, colon, eye, & lung > bone, brain, cervix, ear, heart, kidney, muscle, nerve, pancreas, prostate, skin, stomach, & testis

Notes

• seems to have lost most of the His in the loop between the 4th & 5th transmembrane regions

More general terms

• transmembrane 6 protein
• solute carrier family 30 (SLC30, SLC30A)
• Zn+2 transporter

Database

• UniProt: http://www.uniprot.org/uniprot/Q6NXT4.html