phospholipid-transporting ATPase 1A; ATPase class 1 type 8A member 1; chromaffin granule ATPase 2 (ATP8A1, ATPIA)

Function

• may play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes & the maintenance of asymmetric distribution of phospholipids, mainly in secretory vesicles

ATP + H2O + phospholipid(In) = ADP + phosphate + phospholipid(out)

Structure

• belongs to the cation transport ATPase (P-type) (TC 3.A.3) family, type IV subfamily

Compartment

• cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane
• multi-pass membrane protein

Alternative splicing

named isoforms=3

Expression

• expressed in most adult tissues
• not expressed in liver, testis & placenta
• most abundant in heart, brain & skeletal muscle
• also detected in fetal tissues
• isoform 1 is only detected in brain, skeletal muscle & heart & is the most abundant form in skeletal muscle

More general terms

• phospholipid-transporting ATPase
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10396
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10396
• OMIM: https://mirror.omim.org/entry/609542
• UniProt: http://www.uniprot.org/uniprot/Q9Y2Q0.html